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Tuesday, May 7, 2013
UF launches HiPerGator, the state's most powerful supercomputer
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Public release date: 7-May-2013[ | E-mail |
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University of Florida
GAINESVILLE, Fla. The University of Florida today unveiled the state's most powerful supercomputer, a machine that will help researchers find life-saving drugs, make decades-long weather forecasts and improve armor for troops.
The HiPerGator supercomputer and recent tenfold increase in the size of the university's data pipeline make UF one of the nation's leading public universities in research computing.
"If we expect our researchers to be at the forefront of their fields, we need to make sure they have the most powerful tools available to science, and HiPerGator is one of those tools," UF President Bernie Machen said. "The computer removes the physical limitations on what scientists and engineers can discover. It frees them to follow their imaginations wherever they lead."
For UF immunologist David Ostrov, HiPerGator will slash a months-long test to identify safe drugs to a single eight-hour work day.
"HiPerGator can help get drugs get from the computer to the clinic more quickly. We want to discover and deliver safe, effective therapies that protect or restore people's health as soon as we can," Ostrov said. "UF's supercomputer will allow me to spend my time on research instead of computing."
The Dell machine has a peak speed of 150 trillion calculations per second. Put another way, if each calculation were a word in a book, HiPerGator could read the millions of volumes in UF libraries several hundred times per second.
UF worked with Dell, Terascala, Mellanox and AMD to build a machine that makes supercomputing power available to all UF faculty and their collaborators and spreads HiPerGator's computing power over multiple simultaneous jobs instead of focused on a single task at warp speed. HiPerGator features the latest in high-performance computing technology from Dell and AMD with 16,384 processing cores; a Dell|Terascala HPC Storage Solution (DT-HSS 4.5) with the industry's fastest open-source parallel file system; and Mellanox's FDR 56Gb/s InfiniBand interconnects that provide the highest bandwidth and lowest latency. Together these features provide UF researchers unprecedented computation and faster access to data to quickly further their research.
UF unveiled HiPerGator on Tuesday as part of a ribbon-cutting ceremony for the 25,000-square-foot UF Data Center built to house it. HiPerGator was purchased and assembled for $3.4 million, and the Data Center was built for $15 million.
Also today, the university announced that it is the first in the nation to fully implement the Internet2 Innovation Platform, a combination of new technologies and services that will further speed research computing.
###
Media Contact
Chris Moran, chrismoran@ufl.edu
Contact
Erik Deumens, deumens@ufl.edu
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 7-May-2013[ | E-mail |
Share ] Contact: Erik Deumens
deumens@ufl.edu
352-328-4495
University of Florida
GAINESVILLE, Fla. The University of Florida today unveiled the state's most powerful supercomputer, a machine that will help researchers find life-saving drugs, make decades-long weather forecasts and improve armor for troops.
The HiPerGator supercomputer and recent tenfold increase in the size of the university's data pipeline make UF one of the nation's leading public universities in research computing.
"If we expect our researchers to be at the forefront of their fields, we need to make sure they have the most powerful tools available to science, and HiPerGator is one of those tools," UF President Bernie Machen said. "The computer removes the physical limitations on what scientists and engineers can discover. It frees them to follow their imaginations wherever they lead."
For UF immunologist David Ostrov, HiPerGator will slash a months-long test to identify safe drugs to a single eight-hour work day.
"HiPerGator can help get drugs get from the computer to the clinic more quickly. We want to discover and deliver safe, effective therapies that protect or restore people's health as soon as we can," Ostrov said. "UF's supercomputer will allow me to spend my time on research instead of computing."
The Dell machine has a peak speed of 150 trillion calculations per second. Put another way, if each calculation were a word in a book, HiPerGator could read the millions of volumes in UF libraries several hundred times per second.
UF worked with Dell, Terascala, Mellanox and AMD to build a machine that makes supercomputing power available to all UF faculty and their collaborators and spreads HiPerGator's computing power over multiple simultaneous jobs instead of focused on a single task at warp speed. HiPerGator features the latest in high-performance computing technology from Dell and AMD with 16,384 processing cores; a Dell|Terascala HPC Storage Solution (DT-HSS 4.5) with the industry's fastest open-source parallel file system; and Mellanox's FDR 56Gb/s InfiniBand interconnects that provide the highest bandwidth and lowest latency. Together these features provide UF researchers unprecedented computation and faster access to data to quickly further their research.
UF unveiled HiPerGator on Tuesday as part of a ribbon-cutting ceremony for the 25,000-square-foot UF Data Center built to house it. HiPerGator was purchased and assembled for $3.4 million, and the Data Center was built for $15 million.
Also today, the university announced that it is the first in the nation to fully implement the Internet2 Innovation Platform, a combination of new technologies and services that will further speed research computing.
###
Media Contact
Chris Moran, chrismoran@ufl.edu
Contact
Erik Deumens, deumens@ufl.edu
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Source: http://www.eurekalert.org/pub_releases/2013-05/uof-ulh050713.php
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China's unsteady economy seen holding April inflation in check
BEIJING (Reuters) - Subdued factory and investment growth probably capped China's inflation in April and depressed producer prices for a 14th consecutive month, a Reuters poll showed, clouding the outlook for the Chinese economy.
And risks that China's factory and investment growth in April may miss even conservative forecasts are mounting after surveys of the country's manufacturing and services industries cooled unexpectedly last month.
A median for forecasts by 27 economists showed the annual consumer price index ran at 2.3 percent in April, up from 2.1 percent in March but comfortably below the central bank's 3 percent forecast for 2013.
Producer price deflation is forecast at 2.3 percent compared to a year ago, the deepest in six months.
Analysts from Barclays said China's struggling exports sector and its fragile domestic demand have added to the problem of capacity under-utilization, and dampened producer prices.
"The manufacturing sector will face continued pressures from the uncertain external outlook and the modest domestic recovery, and painful adjustments given over-investment and over-capacity," economists from Barclays said in a note.
China's factory output is expected to have grown 9.5 percent in April from a year ago, recovering slightly from a seven-month low hit in March. Fixed-asset investment is forecast to have expanded 21 percent in the first four months from a year earlier, up a shade from 20.9 percent between January and March.
But these estimates may prove optimistic.
Two separate surveys of Chinese factories showed growth slowed in April after new export orders fell, reinforcing doubts about the health of the world's second-biggest economy after its disappointing first quarter.
China's services sector, having hitherto shown greater resilience than factories, has also faltered.
A private survey on Monday showed growth in the services industry in April plumbed 20-month lows after new orders fell to levels last seen in August 2011. An official survey also showed new orders dropping below historical averages.
The dour surveys followed China's first-quarter growth report that showed its economy stumbling. Growth unexpectedly moderated to 7.7 percent from 7.9 percent the previous quarter, hurt by a surprisingly sharp factory cooldown.
Yet most analysts are hopeful China's economic recovery is merely delayed and has not reversed, with a credit boom underpinning growth. Credit ballooned nearly 60 percent in the first quarter from a year ago, fuelling future inflation risks.
(Reporting by Beijing Economics; Writing by Koh Gui Qing; Editing by Simon Cameron-Moore)
Source: http://news.yahoo.com/chinas-unsteady-economy-seen-holding-april-inflation-check-042729606.html
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Rose not ruling out return, Deng out for Game 1
Chicago Bulls forward Luol Deng (9) reacts in the second half of Game 5 of their first-round NBA basketball playoff series against the Brooklyn Nets, Monday, April 29, 2013, in New York. The Nets won 110-91. (AP Photo/Kathy Willens)
Chicago Bulls forward Luol Deng (9) reacts in the second half of Game 5 of their first-round NBA basketball playoff series against the Brooklyn Nets, Monday, April 29, 2013, in New York. The Nets won 110-91. (AP Photo/Kathy Willens)
Miami Heat's Dwyane Wade smiles after team practice at American Airlines Arena in Miami on Friday, May 3, 2013. (AP Photo/El Nuevo Herald, David Santiago) MAGS OUT NO SALES
Chicago Bulls forward Luol Deng, right, defends against Brooklyn Nets forward Gerald Wallace (45) in the first half of Game 5 of their first-round NBA basketball playoff series, Monday, April 29, 2013, in New York. (AP Photo/Kathy Willens)
MIAMI (AP) ? Derrick Rose still has not ruled out a return this season for the Chicago Bulls, saying he could play in their Eastern Conference semifinal against the Miami Heat.
The 2011 NBA MVP will not play for Chicago in Game 1 against Miami on Monday night, nor will forward Luol Deng or guard Kirk Hinrich. Deng returned to a hospital for more tests, the Bulls said, and underwent a spinal tap to rule out viral meningitis after becoming ill last week. Hinrich will miss his fourth straight game with a calf injury.
Rose has not played in more than a year while recovering from reconstructive knee surgery. He was hurt in last season's playoffs.
"Still in the air," Rose said Monday before the Bulls went through a game-day practice in Miami. "I might have a chance."
So might Hinrich and Deng, both of whom are listed as day-to-day by the Bulls. Hinrich is trying to work through the calf problem, and Bulls coach Tom Thibodeau said Deng should be flying to Miami on Tuesday.
"He's feeling a little better," Thibodeau said.
Without Hinrich, the Bulls lose one of their best defenders against Dwyane Wade ? who has been bothered for several weeks by bone bruises around his right knee. Hinrich has been rehabbing and trying to return to the lineup.
"It's slow, steady progress," Thibodeau said. "But he's still not there."
Thibodeau said Deng was no longer in the hospital when the two spoke Monday morning.
"Lu's been a very important part of the team, sort of the glue of our team," Thibodeau said. "That being said, he's missed games during the season. He missed games in the last series. We have more than enough to get it done and that's what we have to do."
Miami's main injury concern heading into the series is the status of Wade, who was in the Heat starting lineup along the rest of the regulars ? LeBron James, Udonis Haslem, Chris Bosh and Mario Chalmers.
"Thinking I'm ready to go," Wade said.
The Bulls had a starting lineup of Jimmy Butler, Carlos Boozer, Joakim Noah, Marco Belinelli and Nate Robinson.
The will-Rose-play-again-this-season question has loomed over the Bulls for several weeks, and the point guard himself said Monday he was "feeling pretty good."
He works out before most games, doing shooting and other drills, and was in practice garb when his teammates went through final preparations for Game 1 on the floor of Miami's arena on Monday.
"My spirits are up," Rose said. "Just happy to be here. My family is here. My teammates are here. Just everybody that we need."
Rose said Deng's absence does not have him feeling pressure to rejoin the lineup.
"I haven't had any pressure from anyone ? not in the organization, not from my teammates," Rose said. "They know I'm putting everything I have into trying to come back as fast as possible. But just trying to be smart with the whole situation and just take my time."
Thibodeau was far from committal when asked if Rose could play against Miami.
"We'll see," he said.
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Monday, May 6, 2013
What's Your Grubbiest Tech Confession?
Nobody's perfect. Some people Skype without a headset in public
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Solar Eclipse Turns Sun Into 'Ring of Fire' This Week
The moon will block the sun in a potentially spectacular solar eclipse this week ? a celestial event that will transform the sun into a cosmic "ring of fire" in the daytime sky.
The ring-shaped?solar eclipse ,?known as an annular eclipse, will occur Thursday and Friday (May 9 and 10) ?Eastern time. Weather permitting, the eclipse will be visible in certain parts of Australia and the Southern Pacific Ocean, where the local time will be Friday.
"Solar eclipses can be inspirational to students and others, so it is interesting to have everyone view the eclipse, but only safe methods of viewing should be used," Jay Pasachoff, an astronomer at Williams College and chair of the International Astronomical Union's working group on eclipses, said in a statement. [See Spectacular Photos of a 'Ring of Fire' Solar Eclipse]
While nearly 95 percent of the sun will be covered by the moon at the eclipse's peak, the sky will not be noticeably darker to the naked eye at any point, explained Williams College officials in Williamstown, Mass.
For this reason, special protective lenses, camera and telescope filters and other methods of protection should be used in order to safely watch the eclipse even during full annularity, when the sun is silhouetting the moon.
The path of annularity passes through parts of Papua New Guinea, the Solomon Islands, and Western Australia, the Northern Territory and Queensland in Australia. Other nearby parts of the world will be able to see a partial solar eclipse, if weather permits.
The Hawaiian Islands, other parts of Australia, the southern Philippines, eastern Indonesia, other areas in Papua New Guinea and a small part of New Zealand will get at least a partial show, Williams College officials said.
The entire world should be able to catch a glimpse of the annular eclipse thanks to the online Slooh Space Camera. Slooh will host a webcast featuring expert commentary and views of the eclipse on Thursday starting at 5:30 p.m. EDT (2130 GMT). You can watch the broadcast live on SPACE.com.
During annular solar eclipses, the moon casts a shadow on the face of the Earth when it passes between the planet and the star. Because of its orbit, however, the moon still appears about 4.5 percent smaller than the sun, creating the distinct ring in the sky, Joe Rao, a SPACE.com contributor and meteorologist said.
This week's solar eclipse comes on the heels of a partial lunar eclipse that shadowed the moon above Central Asia, Western Australia, Eastern Europe and Africa. ?Another minor lunar eclipse will occur on May 24.
These aren't the only eclipses of 2013. On Nov. 3, a rare hybrid solar eclipse ? an annular eclipse that transitions into a total eclipse ? will be visible in the northern Atlantic Ocean and into equatorial Africa.
WARNING: Never look directly at the sun during an eclipse with a telescope or your unaided eye. Severe eye damage can result and scientists use special filters to safely view the sun.
Editor's note: If you live in the observing area of Thursday's solar eclipse and safely snap an amazing picture of the sun that you'd like to share for a possible story or image gallery, send photos, comments and your name and location to managing editor Tariq Malik at spacephotos@space.com.
Follow Miriam Kramer on Twitter and Google+. Follow us on Twitter, Facebook?and Google+. Original article on SPACE.com.
Copyright 2013 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.Source: http://news.yahoo.com/solar-eclipse-turns-sun-ring-fire-week-173132339.html
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Sunday, May 5, 2013
Airline lipstick ban: Is red lipstick unIslamic?
Airline lipstick ban: Turkey's national airline banned red lipstick and nail polish for its flight attendants. The ban is prompting a backlash among some secular Turks.
A Turkish Airlines aircraft at Aden Ade International airport in Mogadishu, Somalia. The airlines has banned certain colors of lipstick and nail polish from being used by its cabin crew.
AP
EnlargeTurkey's national airline has barred female flight attendants from wearing red lipstick and nail polish, striking a nerve among secular Turks worried the country is becoming more Islamic.
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Turkish Airlines, Europe's fourth-biggest carrier, said the ban was aimed at keeping crews "artless and well-groomed with makeup in pastel tones", as a natural look improved communication with passengers.
"As a consequence of our current cabin uniforms not including red, dark pink, et cetera, the use of lipstick and nail polish in these colors by our cabin crew impairs visual integrity," the statement said.
Turkish Airlines declined a request for further comment.
The guideline follows other restrictions on employees' appearance and on serving alcohol. Critics say they reflect the influence of the government's conservative religious values at the fast-growing state-run airline, one of Turkey's most recognized brands.
"This new guideline is totally down to Turkish Airlines management's desire to shape the company to fit its own political and ideological stance," Atilay Aycin, president of the airline's Hava-Is labour union, told Reuters.
"No one can deny that Turkey has become a more conservative, religious country."
Turkey is 99 percent Muslim but the NATO state and European Union candidate has a secular constitution.
Prime Minister Tayyip Erdogan's ruling AK Party, which traces its roots to a banned Islamic party, has relaxed the state's control over the expression of religion, such as once-strict limits imposed on wearing the Islamic-style headscarf.
Such restrictions were aimed at reining in Islamism and improving women's rights, but effectively prevented many devout women from studying at university or taking government jobs.
Turkish Airlines scrapped its own ban on the headscarf more than a year ago, and covered women now work at check-in counters and at other positions in the company, Aycin said.
Other Turkish carriers also have guidelines on the appearance of cabin personnel.
HIDDEN AGENDA?
The flag carrier caused a stir earlier this year when newspapers published mockups of a new Ottoman-style uniform for stewardesses with ankle-length dresses, a proposal the airline's management appears to have since abandoned.
That was followed by a ban on alcohol on planes flying to most domestic destinations and some Islamic countries.
"They are objecting to the lipstick and nail polish that we have been using for years," said Asli Gokmen, 30, a flight attendant who lost her job with more than 300 others last year during a union protest and is petitioning for her position back.
No current employees were available for comment.
Turks worried the government is undermining the country's secular order see a hidden agenda.
On Twitter, women posted pictures after applying red lipstick. One wrote: "Why not just ban stewardesses altogether so we can all breathe a sigh of relief?"
Some male Twitter users were indignant over the insinuation that red lipstick would induce a sexual frenzy.
Turkish Airlines passenger Ahmet Yerli, 33, said he did not think the new guideline was a sign of creeping Islamisation but that the ban was still "absurd."
"I've never heard of a plane crashing because of a women's lipstick," he said before his flight.
(Additional reporting by Omer Berberoglu; Editing by Nick Tattersall, John Stonestreet)
Source: http://rss.csmonitor.com/~r/feeds/csm/~3/A64JdxoCPoU/Airline-lipstick-ban-Is-red-lipstick-unIslamic
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Saturday, May 4, 2013
Google Play comes to Barnes & Noble's Nook HD and HD+, we go hands-on (video)
Barnes & Noble's refusal to open its ecosystem has long been one of our primary complaints about the company's tablet offerings. The Nook HD and HD+ are extremely nice pieces of hardware that have been held back by their own walled software offerings -- having a fast device with a nice screen only gets you so far without the proper apps. The company line up to now has been that walling off content allows for a sort of quality control, assuring that apps are developed specifically for the unique form factor of its devices. And while there's perhaps something to be said for that sentiment in the sometimes-fragmented world of Android devices, it was hard to ignore the fact that offering up exclusive access to content through your own marketplace assures better cash flow. It also, unfortunately, means that without extensive developer outreach, there are sure to be plenty of popular apps that just never make it over to your side of the fence.
With its announcement tonight, B&N acknowledges that, in this case, open is better. The company has responded directly to user feedback and will be issuing a software update to its Nook HD and Nook HD+ devices (sorry Nook Tablet and Color owners) that brings Google Play directly to the desktop. The software will come pre-loaded on new devices and will be available as an over-the-air update. If you can't wait that long, you'll also be able to download it directly from the bookseller's site. The update also brings a few other tweaks to the system, but this is far and away the biggest news. The first question we asked upon getting a quick demo: will you be able to buy content like books, magazines and movies through Play? Yep, that's coming too.
Filed under: Tablets, Software, Google
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Obama says he won't comment on Israeli airstrike
President Barack Obama listens a question as he participates in an economic forum in San Jose, Costa Rica, Saturday, May 4, 2013. (AP Photo/Moises Castillo)
President Barack Obama listens a question as he participates in an economic forum in San Jose, Costa Rica, Saturday, May 4, 2013. (AP Photo/Moises Castillo)
SAN JOSE, Costa Rica (AP) ? President Barack Obama says he won't comment on an Israeli airstrike against Syria that targeted a shipment of advanced missiles believed to be headed for the Lebanese militant group Hezbollah.
Israeli officials on Saturday confirmed the strike, which took place early Friday.
Obama told the Spanish-language network Telemundo in an interview that he will defer to the Israeli government for comment. He also repeated his view that the Israelis justifiably have to guard against the transfer of advanced weapons to organizations like Hezbollah. The U.S. considers Hezbollah a terrorist organization.
Obama conducted the interview Saturday, and a portion of the president's answer to a question about the airstrike was broadcast on MSNBC.
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Friday, May 3, 2013
NRA to meet in Texas after blocking gun control in Congress
By Corrie MacLaggan
AUSTIN, Texas (Reuters) - Tens of thousands of National Rifle Association members gather in Houston this weekend for the first time since the Senate rejected a plan last month to expand background checks for gun buyers, but officials say attendees will not sit back to celebrate victory.
"We view it as an opening battle in what will be a multi-year war," said Andrew Arulanandam, a spokesman for the NRA, which lobbied against the proposal. "We're definitely not resting on our laurels."
Polls show more than 80 percent of Americans support expanded background checks, but the proposal to extend background checks for sales made online and at gun shows fell six votes shy on April 17 of the 60 votes needed to clear a procedural hurdle in the Senate.
The proposal, which supporters have vowed to revive, is a key part of President Barack Obama's gun-control effort sparked by the school massacre in Newtown, Connecticut.
The vote was a sign of the influence of the gun lobby, particularly the NRA, which spent $18.6 million in the 2012 campaign cycle, according to the Sunlight Foundation. The NRA has more than 4 million members.
The NRA gathering in the nation's fourth-largest city, which starts Friday and continues through Sunday, is billed as a celebration of the Second Amendment to the U.S. Constitution setting out the right to bear arms.
The event is expected to draw some 70,000 attendees who can stroll 400,000 square feet of displays to see the latest products from firearm manufacturers and hunting outfitters, check out wildlife art and shooting accessories, or sign up for hunting trips around the world. It will also draw protesters who plan to demonstrate for more gun-control measures such as background checks.
There will also be a Stand and Fight Rally with political commentator Glenn Beck, a country music jam featuring the Eli Young Band, and remarks from leading gun rights advocates including former Alaska Governor Sarah Palin, Texas Governor Rick Perry and Louisiana Governor Bobby Jindal.
Since last year's NRA Annual Meetings & Exhibits in St. Louis, Missouri, a national debate about gun laws sprang up after the December shooting at Newtown's Sandy Hook Elementary School, where 20 children and six adults were killed. In the months that followed, states including Connecticut, Colorado, Maryland and New York have passed gun-control laws, while states such as Arkansas, Wyoming and South Dakota have loosened gun restrictions.
"Almost from the moment of the tragedy in Newtown, it became apparent that the ensuing push for a wide variety of new anti-gun laws had a lot less to do with school safety than it did with a decades-long crusade to destroy the Second Amendment," NRA chief executive officer Wayne LaPierre wrote in an op-ed in the Houston Chronicle published in advance of the national gathering.
NRA members proposed solutions such as fixing the mental health system, putting armed guards into schools and enforcing existing federal laws against drug dealers and gang members with guns, LaPierre wrote.
"NRA members exemplify everything that's good and right about America," he wrote.
Those members will be warmly welcomed by leaders in Texas, including Perry and U.S. Senator Ted Cruz, both Republicans.
On Wednesday, Perry celebrated the recent move from California to Texas of a company called Shield Tactical, which sells firearm-related gear and training services. Perry's office said the governor has reached out to more than 30 firearms manufacturers in states that are considering curbing guns sales or manufacturing, urging them to move to Texas.
The NRA's opponents are also gearing up for the Houston event. The local chapter of a group called Moms Demand Action for Gun Sense in America plans to demonstrate in support of background-check legislation. Military veterans who disagree with NRA positions on guns plan an "Occupy the NRA" event.
"The NRA leadership actively worked to block background checks for gun sales, spreading lies about the Senate bill," Lauren Weiner, a spokeswoman for the advocacy group Americans United for Change, told reporters on Thursday. "The reality is that the majority of gun owners do, in fact, support these common-sense reforms."
An online Reuters/Ipsos poll released in January showed that 86 percent of Americans surveyed favored expanded background checks of all gun buyers. A CBS News/New York Times poll released on Wednesday showed that 88 percent of Americans support background checks for all gun buyers and that 59 percent are disappointed or angry about the recent Senate vote on gun legislation.
State Representative Garnet Coleman, a Houston Democrat whose district includes the convention center hosting the NRA meeting, will not be among the Texas politicians at the event.
"Clearly, the sales and promotion of firearms is big business," Coleman said. "This is business with politics as the cloak."
(Reporting By Corrie MacLaggan; Editing by David Gregorio)
Source: http://news.yahoo.com/nra-meet-texas-blocking-gun-control-congress-181434598.html
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Potential novel treatment for influenza discovered: Scientists pursue new therapies as deadly H7N9 flu spreads in China
May 1, 2013 ? An experimental drug has shown promise in treating influenza, preventing lung injury and death from the virus in preclinical studies, according to University of Maryland School of Medicine researchers publishing in the journal Nature on May 1. The scientists found that a drug called Eritoran can protect mice from death after they have been infected with a lethal dose of influenza virus. The potential value of this drug as single therapy or in combination with antivirals is further supported by previous research that found that it is safe for use in humans.
The findings are of particular interest to scientists now that the latest deadly strain of flu, H7N9, is spreading in China -- 82 people in China had been infected with the new strain of flu virus as of April 26, and 17 had died.
Previous scientific studies have revealed that acute lung injury caused by the influenza virus is the result of an immune reaction mediated by a protein called Toll-like receptor 4 (TLR4). Senior author Stefanie Vogel, Ph.D., Professor of Microbiology and Immunology and Medicine at the University of Maryland, and colleagues previously demonstrated that mice that lack the ability to signal through TLR4 are highly refractory to influenza-induced lethality. In their new study, they extend these findings by showing that Eritoran -- a synthetic inhibitor of TLR4, originally developed by Eisai Inc. for treatment of sepsis -- improved clinical symptoms and prevented death when administered up to six days after infection with the influenza virus. Existing antiviral medications must be administered within two days of infection to be optimally effective.
Annual influenza epidemics are estimated to result in 3 million to 5 million cases of severe illness and 250,000 to 500,000 deaths yearly worldwide. The virus is continually evolving and new variants give rise to seasonal outbreaks. Increasing resistance to existing antiviral therapies and the short time-frame in which these agents are effective highlight the critical need for new treatments, such as Eritoran. This study was funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
"Currently, vaccines and antiviral medications are the two main approaches to preventing influenza," says Dr. Vogel. "Problems associated vaccine development may limit efficacy and/or vaccine availability. In addition, people suffering from influenza may not go to the doctor or to the emergency room in time for the antivirals to be effective. Also, as the flu adapts to resist existing treatments, we are in search of new therapies to save lives and prevent severe illness. Our research seems to show that Eritoran could provide doctors with a new tool in their flu-fighting toolbox, as well as several more days to treat the sickest of patients successfully. More basic research is needed, but we are hopeful that this medication could one day change the way that we treat severe influenza and possibly other pathogens that cause disease by a similar mechanism."
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The above story is reprinted from materials provided by University of Maryland Medical Center.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Kari Ann Shirey, Wendy Lai, Alison J. Scott, Michael Lipsky, Pragnesh Mistry, Lioubov M. Pletneva, Christopher L. Karp, Jaclyn McAlees, Theresa L. Gioannini, Jerrold Weiss, Wilbur H. Chen, Robert K. Ernst, Daniel P. Rossignol, Fabian Gusovsky, Jorge C. G. Blanco, Stefanie N. Vogel. The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature, 2013; DOI: 10.1038/nature12118
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/Gg2NTwnMfBU/130501154440.htm
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